Delivering a Targeted Payload

Receptor-mediated delivery of proven therapeutic agents

  1. CD206 Targeting: Macrophage Therapeutics’ (MT) proprietary Activated Macrophage targeting platform binds to the CD206 receptor, which is only expressed on Activated Macrophages of the immune system.
  2. Internalization: The conjugated drug payload (currently inactivated) and MT delivery backbone are internalized by the CD206 receptor of the Activated Macrophage.
  3. PH Sensitive Release: Once internalized, a drop in PH cleaves the conjugated drug payload which activates the therapeutic agent to modulate (MT-2000 class) or destroy (MT-1000 class) the targeted Activated Macrophage.

MT GPS Mechanism

Our Target

pH Sensitive Drug Activation

Drug Activation