Delivering a Targeted Payload
Receptor-mediated delivery of proven therapeutic agents
- CD206 Targeting: Macrophage Therapeutics’ (MT) proprietary Activated Macrophage targeting platform binds to the CD206 receptor, which is only expressed on Activated Macrophages of the immune system.
- Internalization: The conjugated drug payload (currently inactivated) and MT delivery backbone are internalized by the CD206 receptor of the Activated Macrophage.
- PH Sensitive Release: Once internalized, a drop in PH cleaves the conjugated drug payload which activates the therapeutic agent to modulate (MT-2000 class) or destroy (MT-1000 class) the targeted Activated Macrophage.
pH Sensitive Drug Activation